Trayodashanga Guggulu is famous prescription in Vata and Vatakapha diseases viz various Neuro muscular diseases like low back pain, Various joint pains, Jaw immobility, Shoulder pain, lower limb Pain, Bone pain, Muscular Pain, Pains during menstruation, pain in chest, Radiating pains, Sciatic Pain, Paralysis or hemiparesis, Difficult walking